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Search: WFRF:(Zhang Mei Jie) > Sandmaier Brenda M. > Cytogenetic Risk De...

Cytogenetic Risk Determines Outcomes After Allogeneic Transplantation in Older Patients With Acute Myeloid Leukemia in Their Second Complete Remission : A Center for International Blood and Marrow Transplant Research Cohort Analysis

Michelis, Fotios V. (author)
Princes Margaret Canc Ctr, Allogene Blood & Marrow Transplant Program, Toronto, ON, Canada.
Gupta, Vikas (author)
Princes Margaret Canc Ctr, Allogene Blood & Marrow Transplant Program, Toronto, ON, Canada.
Zhang, Mei-Jie (author)
Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA.
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Wang, Hai-Lin (author)
Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.
Aljurf, Mahmoud (author)
Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.;King Faisal Specialist Hosp Ctr & Res, Dept Oncol, Riyadh, Saudi Arabia.
Bacher, Ulrike (author)
Univ Med Gottingen, Dept Hematol Oncol, Gottingen, Germany.;Univ Canc Ctr Hamburg, Interdisciplinary Clin Stem Cell Transplantat, Hamburg, Germany.
Beitinjaneh, Amer (author)
Univ Miami, Miami, FL USA.
Chen, Yi-Bin (author)
Massachusetts Gen Hosp, Div Hematol Oncol, Boston, MA 02114 USA.
DeFilipp, Zachariah (author)
Emory Univ Hosp, 1364 Clifton Rd NE, Atlanta, GA 30322 USA.
Gale, Robert Peter (author)
Imperial Coll London, Dept Med, Div Expt Med, Hematol Res Ctr, London, England.
Kebriaei, Partow (author)
Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.
Kharfan-Dabaja, Mohamed (author)
H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
Lazarus, Hillard M. (author)
Univ Hosp, Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.
Nishihori, Taiga (author)
H Lee Moffitt Canc Ctr & Res Inst, Dept Blood & Marrow Transplantat, Tampa, FL USA.
Olsson, Richard F. (author)
Karolinska Institutet,Uppsala universitet,Centrum för klinisk forskning i Sörmland (CKFD),Karolinska Inst, Dept Lab Med, Div Therapeut Immunol, Stockholm, Sweden
Oran, Betul (author)
Imperial Coll London, Dept Med, Div Expt Med, Hematol Res Ctr, London, England.;Univ Texas MD Anderson Canc Ctr, Dept Stem Cell Transplantat, Div Canc Med, Houston, TX 77030 USA.
Rashidi, Armin (author)
Washington Univ, Sch Med, Div Oncol, St Louis, MO USA.
Rizzieri, David A. (author)
Duke Univ, Div Hematol Malignancies & Cellular Therapy, Durham, NC USA.
Tallman, Martin S. (author)
Mem Sloan Kettering Canc Ctr, Dept Med, Leukemia Serv, 1275 York Ave, New York, NY 10021 USA.
de Lima, Marcos (author)
Univ Hosp, Case Med Ctr, Seidman Canc Ctr, Dept Med, Cleveland, OH USA.
Khoury, H. Jean (author)
Emory Univ Hosp, 1364 Clifton Rd NE, Atlanta, GA 30322 USA.
Sandmaier, Brenda M. (author)
Univ Washington, Div Med Oncol, Seattle, WA 98195 USA.;Fred Hutchinson Canc Res Ctr, Div Clin Res, 1124 Columbia St, Seattle, WA 98104 USA.
Weisdorf, Daniel (author)
Univ Minnesota, Med Ctr, Dept Med, Div Hematol Oncol & Transplantat, Minneapolis, MN 55455 USA.
Saber, Wael (author)
Med Coll Wisconsin, Ctr Int Blood & Marrow Transplant Res, Dept Med, Milwaukee, WI 53226 USA.
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Princes Margaret Canc Ctr, Allogene Blood & Marrow Transplant Program, Toronto, ON, Canada Med Coll Wisconsin, Inst Hlth & Soc, Div Biostat, Milwaukee, WI 53226 USA. (creator_code:org_t)
2017-01-24
2017
English.
In: Cancer. - : WILEY. - 0008-543X .- 1097-0142. ; 123:11, s. 2035-2042
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND Allogeneic hematopoietic cell transplantation (HCT) offers curative potential to a number of older patients with acute myeloid leukemia (AML) in their first complete remission. However, there are limited data in the literature concerning post-HCT outcomes for older patients in their second complete remission (CR2).METHODS The purpose of the current study was to retrospectively investigate within the Center for International Blood and Marrow Transplant Research database parameters influencing post-transplant outcomes for patients 60 years of age or older undergoing HCT for AML in CR2.RESULTS In total, 196 patients from 78 centers were identified; the median age was 64 years (range, 60-78 years). Seventy-one percent had a Karnofsky performance status >= 90 at the time of HCT. Reduced-intensity conditioning regimens were used in 159 patients (81%). A univariate analysis demonstrated a 3-year overall survival (OS) rate of 42% (95% confidence interval [CI], 35%-49%), a leukemia-free survival rate of 37% (95% CI, 30%-44%), a cumulative incidence of nonrelapse mortality of 25% (95% CI, 19%-32%), and a cumulative incidence of relapse (CIR) of 38% (95% CI, 31%-45%). A multivariate analysis demonstrated that cytogenetic risk was the only independent risk factor for OS (P=.023) with a hazard ratio (HR) of 1.14 (95% CI, 0.59-2.19) for intermediate-risk cytogenetics and an HR of 2.32 (95% CI, 1.05-5.14) for unfavorable-risk cytogenetics. For CIR, cytogenetic risk was also the only independent prognostic factor (P=.01) with an HR of 1.10 (95% CI, 0.47-2.56) for intermediate-risk cytogenetics and an HR of 2.98 (95% CI, 1.11-8.00) for unfavorable-risk cytogenetics.CONCLUSIONS Allogeneic HCT is a curative treatment option for older patients with AML in CR2, particularly for those with favorable or intermediate cytogenetic risk.

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cancer and Oncology (hsv//eng)

Keyword

acute myeloid leukemia (AML)
allogeneic transplant
Center for International Blood and Marrow Transplant Research (CIBMTR)
elderly
second complete remission

Publication and Content Type

ref (subject category)
art (subject category)

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